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Frequently Asked Questions
SysChem as a Business
The SysChem Product
The Science
Behind the Product
The
Computing Behind SystematiChem©
Why should a Customer Do Business with SysChem?
Why Is
SysChem a good investment?
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SysChem as a Business
What,
exactly, is SysChem selling?
SysChem is selling
information that saves chemical companies money.
SysChem’s product is less expensive methods for
manufacturing almost any synthetic organic molecule.
How does
SysChem process an order?
SysChem acts as an organic chemistry service bureau.
Customers order a molecule from SysChem via the
Internet. Once payment terms are negotiated, SysChem
performs an automated retrosynthesis of the molecule.
SysChem then produces a categorized collection of
possible production paths for synthesizing the molecule,
utilizing commonly available materials and proven
chemical reactions.
What will the customer receive from SysChem?
The customer receives a selection of the best
manufacturing methods for whichever molecule(s) it
chooses to submit.
What does the customer do with the results?
The customer chooses the manufacturing pathway that
works best for its purpose. The solution is owned
exclusively by the customer that purchased it. The
customer may then apply for a patent on that process.
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The SysChem Product
Is
SysChem selling a software package?
No. Companies wishing SysChem services will not license
or own software produced and sold by SysChem. Companies
send an image of the molecule to SysChem. SysChem runs
the molecule through its proprietary software to find
the best manufacturing method. The company receives the
answer, which it can examine and manipulate through a
free viewer provided by SysChem. The client can process
and store the data received in any form it wishes, using
its own commercial or proprietary software.
How fast can SystematiChem© process a molecule?
Currently, SysChem can process a molecule in fewer than
24 hours and have the full detailed results ready for
shipping to the customer within 7 business days.
Are there plans to decrease the time needed to process a
molecule?
SysChem plans to acquire faster computers and is
improving its software to reduce both processing and
turn-around times for a molecule. SystematiChem©,
SysChem’s revolutionary processing system, is constantly
being upgraded.
How many orders can SystematiChem© process a day?
As of today, SysChem can process 10 different molecules
in one day. Planned hardware upgrades will increase
capacity to 120 different molecules per day.
Why would the customer want to sort through
(potentially) thousands of manufacturing pathways?
Given the high cost and unwieldy nature of current
retrosynthesis techniques, having thousands of valid
choices is actually a very good thing. Most chemists
would be delighted to be able to pick and choose between
novel solutions that work. If the chemist wants the
manufacturing path requiring the fewest reactions, it is
there to choose. If the chemist is looking for
something truly creative, SysChem offers options for the
scientist to choose between.
How does SystematiChem© guide the customer to the best
answer?
SystematiChem© software currently does much more than
provide a collection of workable manufacturing
pathways. SystematiChem© sorts all syntheses by the
number of chemical reactions required to complete them,
placing the very best syntheses at the top of the list.
SysChem is currently upgrading SystematiChem© to order
each of the valid syntheses by the cost per mol of the
final product. This upgrade will be available no later
than the first quarter of 2007.
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The Science Behind
the Product
What is a “molecule?”
A
molecule is a collection of connected atoms, the most
basic building blocks. A molecule can be simple or
complex. In the end, all a prescription drug is, is a
complex molecule, produced and marketed by a
pharmaceutical house.
What is a
“manufacturing process?”
A
manufacturing process is systematically creating the
target molecule (e.g., a prescription drug) by doing a
step-by-step construction from simpler building block
molecules. Each combination of these building block
molecules requires a chemical reaction, which is like
the glue that holds them together.
Why is SysChem concerned with reaction costs?
Manufacturing processes can be evaluated by yield or by
cost. Traditionally, chemists focus on yield. Cost is
the better predictor of savings. SystematiChem© makes
it easier to calculate cost.
What do we mean when we say “a molecule is a molecule?”
By definition, all organic molecules must contain at
least one carbon atom (ordinarily many of them). The
chemistry for making all organic molecules is the same
no matter whether the ingredients are “natural,”
synthetic, or a combination of the two. There are many
ways to manufacture a complex molecule. Once the
molecule has been created for a particular purpose or
use, how it was created is irrelevant.
What is synthesis?
Synthesis means putting together. Organic synthesis is
the construction of organic compounds, which are any of
a large class of natural and man-made substances that
contain the element carbon. Organic compounds are the
basis of biochemistry and organic chemistry.
What is
retrosynthesis?
Developing a synthesis route or plan for a desired
compound is referred to as retrosynthesis. The organic
chemist works backwards from the desired target compound
using known reactions until he/she arrives at available
starting materials. SysChem is the first company to
effectively automate this process.
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The Computing Behind
SystematiChem©
Will the customer have access to the source code?
No. The software is proprietary and closely guarded to
discourage piracy.
What programming language are you using?
Although the software itself will never be released, we
are currently using three different computer languages,
which are Delphi, C#, and SQL.
What is the platform?
The current platform is Windows XP, which may change to
Linux at some point in the future.
Do you
hold patents on your product?
Although there are nine major technological
breakthroughs in this software, SysChem chooses not to
patent any of them, as software is far too easy to
pirate once its details are revealed in a patent
application. SysChem’s edge is its overall approach to
retrosynthesis. It will keep that edge by actively
engaging its customers, and constantly improving the
product.
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Why should a Customer Do
Business with SysChem?
What exactly is it that SysChem provides that has value
to a customer, and how is that value determined?
SysChem’s software, SystematiChem©, provides syntheses
that can easily cut manufacturing costs in half or more
for most organic molecules produced today. There are no
gimmicks or spin. These are not “anticipated” savings.
There are no additional steps required to achieve
optimum savings. The customer will be able to
independently calculate tangible cash savings to the
bottom line.
In
addition to distinguishing potential manufacturing
processes by number of steps, will SystematiChem© tell
the customer which manufacturing process is least
expensive?
Upgrades to SystematiChem© will sort results by cost per
mol of the finished product. For US manufacturers, this
will offer reliable information that could be used to
patent the lowest cost process. Companies located in
different parts of the world will have different
advantages and disadvantages in manufacturing such as
labor costs, environmental issues, government
regulation, etc. For these manufacturers, SystematiChem©
will still offer a good place to start.
Do you
have independent test results?
Yes..
What guarantee is there that SystematiChem© actually
works?
The end deliverable is remarkably straightforward. The
customer receives a collection of pathways by which a
desired molecule may be synthesized. The components are
commonly used and available on the open market. All the
reactions are proven and accepted by chemists worldwide.
No one disputes the value of retrosynthetic analysis.
By automating the process, SysChem is simply making a
valuable tool cost-effective
What if the customer doesn’t like the results?
SysChem expects to make sales through nurtured
relationships with decision makers in reputable
companies. As a consequence, SysChem anticipates an
initial sales cycle that includes time for the customer
to determine the usefulness of the product.
If the customer determines that SysChem’s results for a
particular molecule have no value, SysChem will reclaim
the rights to the molecule and void the sale. SysChem
is prepared to risk an occasional pirated molecule in
the name of customer satisfaction.
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Why Is SysChem a
good investment?
What pressing industry problem does SystematiChem©
solve?
Everyone agrees retrosynthetic analysis is the key to
more efficient manufacture of organic compounds. To
date, no one has figured out how to do it quickly,
accurately and inexpensively. The result is that
companies routinely spend 2-10 times more on
manufacturing costs than is necessary. That reduces
profits, increases prices to end-users, or both. With
increased government regulation – including prescription
price controls – on the horizon, the company that can
painlessly reduce costs and increase profits will have
the edge.
Why
didn’t someone else do it first?
Many of the larger pharmaceutical and chemical companies
have been trying to do this for at least two decades.
There are many reasons they have not succeeded.
From the perspective of the inventor of SystematiChem©,
one big reason companies failed to solve this problem is
because they are thinking like chemists. The real
problem is the gap between the ways chemists view the
world and how computers process information. The
solution to bridging the gap is 90% mathematical.
Mastering the puzzle is something best done by a
marriage of the right group of scientific
entrepreneurs. That’s why SysChem got there first. It
is why SysChem will retain its edge.
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